Research

The goal of the research in this department is to understand the molecular mechanism of neural network formation. The development of neural networks depends on various cell-cell and cell-extracellular matrix interactions mediated by many molecules such as cell adhesion molecules, growth factors, extracellular matrix molecules and proteases. Recently, it was found that neural proteoglycans play important roles in the coordination of the signal transduction pathways of these molecules. We are now trying to elucidate the physiological functions of neural proteoglycans.

Outline of Projects

1. Functional analysis of neural proteoglycans in the development of cerebellum especially focussing on the Purkinje cell morphogenesis and mossy fiber formation.
2. Biochemical studies on the signal transduction mechanism of neural proteoglycans.
3. Trial of axon regeneration by proteoglycan remodeling.

Staff