| 1968 April | A committee is formed to investigate the value of establishing the Tokyo Metropolitan Institute for Research on Mental and Physical Disabilities (Provisional Name). |
| 1971 December | A committee is formed to prepare for establishment of the Tokyo Metropolitan Institute for Research on Mental and Physical Disabilities (Provisional Name). |
| 1971 June | The above comittee submits a report entitled, "Organization and Administrative System for Tokyo Metropolitan Institute for Research on Mental and Physical Disabilities" (Provisional Name). |
| 1971 November | A Preparatory Office is formed, for establishing the Tokyo Metropolitan Institute for Research on Mental and Physical Disabilities (Provisional Name). |
| 1972 April | The Tokyo Metropolitan Institute for Neuroscience (TMIN) is opened with seven departments. |
| 1972 July | Dr. Teizo Ogawa is appointed Director. |
| 1973 April | Seven remaining departments are opened (all 14 departments opened). |
| 1976 July | Dr. Masayasu Sato is appointed Director. |
| 1981 November | The Institute is reorganized as a corporate foundation, ceasing to be administered directly by the metropolitan government. |
| 1981 November | Vice-Governor of Tokyo Shinichi Nomura is appointed President. |
| 1983 June | An agreement is formed on academic exchange with the UCLA (University of California, Los Angels ) Brain Reseach Institute. |
| 1983 July | Vice-Governor of Tokyo Tetsuo Kando is appointed President. |
| 1986 February | A symposium is co-sponsored with UCLA Brain Research Institute. |
| 1986 April | Dr. Hiroshi Shimazu is appointed Director. |
| 1987 June | Vice-Governor of Tokyo Tsutomu Manita is appointed President. |
| 1988 February | The TMIN International Symposium is held (renamed as successor to the symposium co-sponsored with UCLA). |
| 1990 August | The Institute is reorganized (structured into four research divisions and 14 departments). |
| 1991 August | Chief of the Bureau of Public Health Satoshi Nakajima is appointed President. |
| 1992 November | The 20th anniversary of TMIN is celebrated. Festschrift is published. |
| 1993 April | Dr. Toshinori Hongo is appointed Director. |
| 1993 July | Chief of the Bureau of Public Health Tadamochi Watanabe is appointed President. |
| 1995 June | Chief of the Bureau of Public Health Yoichi Harayama is appointed President. |
| 1997 December | Dr. Noboru Mizuno is appointed Director. |
| 1999 April | The TMIN was reconstituted as an institute in Tokyo Metropolitan Organization for Medical Research. |
| 1999 june | Chief of the Bureau of Public Health Koichi Imamura is appointed President. |
| 2000 April | The Institute is reorganized (structured into four research divisions and 23 departments). |
| 2002 August | Dr.Tadashi Ogino is appointed President. |
| 2002 October | The 30th anniversary of TMIN is celebrated. Festschrift is published. |